Histomorphological study of the effect of mint on the uterus and ovary of adult Wistar rats

Mentha piperita is a medicinal plant used for treating human diseases thousands of years. However, the traditional usage herbs by humans imperfect and unscientific modern standards. It result countless trial-and-error tests that people have conducted, so points way to natural therapeutic usage. "Natural" does not necessarily mean "safe." This study aimed evaluate effects ethanolic extract leaves on histo-morphological changes in ovary uterus adult female Wistar rats. Hence this was undertaken its impact gonadal organ albino rats 18 age 6-8 weeks which were divided into 3 groups. Group I treated as control, II III received orally 200mg/kg 400mg/kg respectively 60 days. Then sacrificed ovaries processed haematoxylin eosin staining effect estrous phase, ovulation, implantation. The ovarian germinal epithelium found be flattened at places disrupted. stroma shows more fibrosis with severe degeneration. Granulosa cells are also Follicles show features Degenerating oocytes seen places. endometrium lining disrupted, vascularity increased myometrium has become edematous. shown previous studies arvensis, spicate (spearmint), got adverse reproductive system but our fertility, we showed folliculogenesis many degenerated follicles different stages development.